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Anticoagulants: Phenobarbital lowers the plasma amounts of dicumarol (identify Formerly used: bishydroxycoumarin) and will cause a lower in anticoagulant exercise as measured from the prothrombin time. Barbiturates can induce hepatic microsomal enzymes causing enhanced metabolism and lowered anticoagulant response of oral anticoagulants (e.Nitschke